My most wanted villager is Tom. I developed a connection to Tom in City Folk. He's a nice curmudgeon and I just loved hearing him talk and visiting him. The saddest day in my Animal Crossing career (13 years) was when Tom moved away. I hadn't played for a while and found a letter from him in my mailbox saying goodbye. Ever since, I've been hoping to see him again. Hopefully, I'll get the chance in this game.
My most wanted is probably Bill, the duck and Dizzy the elephant. The two of them lived next door to each other in my village on GameCube, and were practically inseparable. It was a sad day when Bill moved away without warning, after two years. I painted his portrait and put it on a sign where his house used to be. *sniff*
It would be cool to see Octavian the octopus again too.
I just don't want Velma again. She was a jerk to me in the GameCube game.
I tried to get her to move on multiple occasions. I wrote letters asking for her to move, I surrounded her house with fifteen pitfalls before she woke up one morning (which was hilarious), stopped doing her favors...but nothing worked. She's still at the bottom of my map.